The oxycodone in OXYCONTIN may possibly boost the frequency of seizures in patients with seizure Diseases and could raise the threat of seizures occurring in other clinical configurations linked to seizures.
This medication may possibly interfere with selected lab tests (for example amylase/lipase ranges), perhaps resulting in Untrue take a look at success. Make sure lab personnel and all your Physicians know you employ this drug.
If Girls take this drug in the course of pregnancy there is a hazard that their new child infants will expertise neonatal withdrawal syndrome.
When working with OXYCONTIN with CYP3A4 inducers or discontinuing CYP3A4 inhibitors, Examine individuals at frequent intervals and think about expanding the opioid dosage if desired to keep up suitable analgesia or if signs and symptoms of opioid withdrawal take place [see Drug Interactions (7)].
Drug withdrawal syndrome may perhaps happen upon abrupt cessation of therapy or dose reduction. When a affected person not calls for therapy, it can be highly recommended to taper the dose progressively to minimise indicators of withdrawal. Tapering from the significant dose could take months to months.
Managed pharmacokinetic scientific studies in elderly sufferers (aged more than sixty five yrs) have revealed that, in contrast with youthful adults, the clearance of oxycodone is only a bit diminished. No untoward adverse drug reactions had been found based on age, therefore Grownup doses and dosage intervals are acceptable.
Consequently the oxycodone dose may perhaps have to be altered appropriately. Some specific examples are delivered underneath:
If concomitant use is warranted, frequently evaluate the patient, notably all through treatment initiation and dose adjustment. Discontinue OXYCONTIN if serotonin syndrome is suspected.
For pediatric sufferers with a program of more than one opioid, work out the approximate oxycodone dose for every opioid and sum the totals to obtain the approximate OXYCONTIN everyday dosage.
Respiratory despair can happen Anytime all through opioid therapy, particularly when initiating and subsequent dosage boosts with OXYCONTIN. Look at this possibility when deciding on an First dose and when creating dose changes [see Warnings and Safeguards (5.2)]. Instruct sufferers to swallow OXYCONTIN tablets total, a person pill at a time, with sufficient water to guarantee finish swallowing immediately soon after positioning while in the mouth.
There may be substantial inter-client variability within the relative potency of different opioid drugs and formulations. For that reason, check here a conservative solution is recommended when determining the full every day dosage of OXYCONTIN.
It needs to be emphasised that it is a guide to your dose of OxyContin tablets demanded. Inter-affected individual variability involves that every affected individual is meticulously titrated to the right dose.
• are allergic to any of its substances. See the close of this Medication Guide for a list of the components in OxyContin.
INDICATIONS AND Use OXYCONTIN is surely an opioid agonist indicated for that management of critical and persistent suffering that requires an prolonged cure period having a every day opioid analgesic and for which different treatment selections are insufficient in:(one) Older people; and